Addition of thoracic radiotherapy to a PD-L1 inhibitor plus chemotherapy regimen delays brain metastasis onset in extensive-stage small cell lung cancer patients without baseline brain metastasis

Addition of thoracic radiotherapy to a PD-L1 inhibitor plus chemotherapy regimen delays brain metastasis onset in extensive-stage small cell lung cancer patients without baseline brain metastasis

Abstract Background With the application of immune checkpoint inhibitors (ICIs) and the discovery of the synergistic effect of radiotherapy and immunotherapy, the intracranial benefit of thoracic radiotherapy (TRT) is receiving signiffcant clinical attention. The purpose of this study was to analyze...

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Bibliographic Details
Main Authors: Baiyang Huang, Senyuan Liu, Kaiyue Wang, Jiarui Zhao, Min Li, Xingpeng Wang, Weiqing Wang, Xiaohan Wang, Jinming Yu, Xue Meng, Guoxin Cai
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Respiratory Research
Subjects:
Extensive-stage small cell lung cancer (ES-SCLC)
Immune checkpoint inhibitors (ICIs)
Brain metastases (BMs)
Thoracic radiotherapy (TRT)
Programmed death-ligand 1 (PD-L1) checkpoint inhibitors
Online Access:https://doi.org/10.1186/s12931-025-03157-1
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https://doi.org/10.1186/s12931-025-03157-1

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