Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations in vitro, in vivo, and in silico

Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations in vitro, in vivo, and in silico

IntroductionAdrenergic activation of protein kinase A (PKA) in cardiac muscle targets the sarcolemma, sarcoplasmic reticulum, and contractile apparatus to increase contractile force and heart rate. In the thin filaments of the contractile apparatus, cardiac troponin I (cTnI) Ser22 and Ser23 in the c...

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Bibliographic Details
Main Authors: Zeyu Yang, Alice M. Sheehan, Andrew E. Messer, Sharmane Tsui, Alexander Sparrow, Charles Redwood, Vladimir Kren, Ian R. Gould, Steven B. Marston
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Physiology
Subjects:
cardiomyopathy
lusitropy
PKA phosphorylation
troponin (cTnI)
myocyte contraction
molecular dynamics simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2024.1489439/full
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https://www.frontiersin.org/articles/10.3389/fphys.2024.1489439/full

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