Hsp47 drives obesity-associated breast cancer progression by enhancing asporin deposition in adipose tissue
Abstract Fibrosis is an important feature of adipose tissue in obese individuals; nevertheless, roles of obesity-associated extracellular matrix (ECM) deposition in breast cancer progression largely remain elusive. Here, we show that expression of Hsp47, a chaperone protein involving collagen secret...
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| Main Authors: | Gaofeng Xiong, Daheng He, Dana Napier, Jing Chen, Haizhu Shi, Chun Li, Paula J. Hurley, Chi Wang, Haining Zhu, Changcheng Zhou, Theresa J. Bocklage, Ren Xu |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | Breast Cancer Research |
| Online Access: | https://doi.org/10.1186/s13058-025-02076-9 |
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