Hsp47 drives obesity-associated breast cancer progression by enhancing asporin deposition in adipose tissue

Abstract Fibrosis is an important feature of adipose tissue in obese individuals; nevertheless, roles of obesity-associated extracellular matrix (ECM) deposition in breast cancer progression largely remain elusive. Here, we show that expression of Hsp47, a chaperone protein involving collagen secret...

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Bibliographic Details
Main Authors: Gaofeng Xiong, Daheng He, Dana Napier, Jing Chen, Haizhu Shi, Chun Li, Paula J. Hurley, Chi Wang, Haining Zhu, Changcheng Zhou, Theresa J. Bocklage, Ren Xu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Breast Cancer Research
Online Access:https://doi.org/10.1186/s13058-025-02076-9
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