Establishment of mouse models for severe pulmonary hypertension through ‘double‐hit’ strategies

Establishment of mouse models for severe pulmonary hypertension through ‘double‐hit’ strategies

Abstract Mouse models are crucial for understanding pulmonary hypertension (PH) mechanisms and developing therapies, but existing mouse models under hypoxia only exhibit mild PH. To address this, we established a double‐hit model combining unilateral pneumonectomy (LPx) or left pulmonary artery liga...

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Bibliographic Details
Main Authors: Lingdan Chen, Xin Chen, Yuhang Huang, Zhuoji Ma, Xiaohui Zeng, Tao Wang
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Experimental Physiology
Subjects:
hypoxia
mouse model
pneumonectomy
pulmonary artery ligation
pulmonary hypertension
Online Access:https://doi.org/10.1113/EP091833
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https://doi.org/10.1113/EP091833

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