Androgen receptor promotes arachidonic acid metabolism and angiogenic microenvironment in AFP-negative hepatocellular carcinoma

Androgen receptor promotes arachidonic acid metabolism and angiogenic microenvironment in AFP-negative hepatocellular carcinoma

Abstract Alpha-fetoprotein (AFP) is a classic biomarker for hepatocellular carcinoma (HCC). AFP-positive HCC (AFP+ HCC) has been intensively investigated; however, the genomic, transcriptomic and microenvironmental characteristics of AFP-negative HCC (AFP− HCC) remain to be deciphered. Here we show...

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Main Authors: Zhilong Lin, Xiaofei Liu, Houwei Wang, Shumin Li, Ziqiang Miao, Jing Yang, Yuting Zhang, Kai Lei, Yifan Wu, Youmei Kang, Ruoyin Zheng, Zonglin Xie, Yixi Wen, Xiaoxue Ren, Chunxiao Liu, Alfred Sze-Lok Cheng, Yubin Xie, Shuling Chen, Ming Kuang, Sui Peng, Zhenwei Peng, Zihao Dai
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61448-z
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https://doi.org/10.1038/s41467-025-61448-z

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