Baicalein from Scutellaria baicalensis mitigates oxidative stress through the IIS pathway in a C. elegans model of ulcerative colitis

Baicalein from Scutellaria baicalensis mitigates oxidative stress through the IIS pathway in a C. elegans model of ulcerative colitis

IntroductionUlcerative colitis (UC) is a chronic, nonspecific inflammatory bowel disease with limited therapeutic options. Baicalein, a phenolic flavonoid extracted from Scutellaria baicalensis, has been traditionally used in Chinese medicine for its potent anti-inflammatory, anti-tumor, and antivir...

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Main Authors: Wei Wang, Xiaoyu Fu, Jianing Xu, Weiguang Lv, Shengnan Han, Yi Wang, Yu Xia, Jing Han, Ke Li, Chenggang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
C. elegans
ulcerative colitis
dextran sodium sulfate
baicalein
IIS pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1592244/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1592244/full

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