Targeting CEA in metastatic triple negative breast cancer with image-guided radiation followed by Fab-mediated chimeric antigen receptor (CAR) T-cell therapy

Targeting CEA in metastatic triple negative breast cancer with image-guided radiation followed by Fab-mediated chimeric antigen receptor (CAR) T-cell therapy

IntroductionAlthough CAR-T cell therapy has limited efficacy against solid tumors, it has been hypothesized that prior treatment with Image-Guided Radiation Therapy (IGRT) would increase CAR-T cell tumor infiltration, leading to improved antigen specific expansion of CAR-T cells.MethodsTo test this...

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Bibliographic Details
Main Authors: Eric Aniogo, Maciej Kujawski, Dennis Awuah, Seung E. Cha, Ruby Espinosa, Susanta Hui, Hemendra Ghimire, Paul J. Yazaki, Christine E. Brown, Xiuli Wang, John E. Shively
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor T cells
triple-negative breast cancer
carcinoembryonic antigen
image-guided radiation therapy
cell immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1499471/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1499471/full

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