SsDiHal: discovery and engineering of a novel tryptophan dihalogenase

SsDiHal: discovery and engineering of a novel tryptophan dihalogenase

Abstract Background Halogenation plays a crucial role in enhancing the properties of small molecules, particularly by making them more effective for applications in agrochemicals and pharmaceuticals. Notably, approximately a quarter of current pharmaceuticals are halogenated. While chemical halogena...

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Bibliographic Details
Main Authors: Hassan Sher, Haley Hardtke, Wenzhu Tang, Jie Ren, Hayat Ullah, Xudong Zhou, Y. Jessie Zhang, Jixun Zhan
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Biological Engineering
Subjects:
Enzymatic halogenation
Trytophan dihalogenase
Catalytic efficiency
Regioselectivity
Protein engineering
Online Access:https://doi.org/10.1186/s13036-025-00518-8
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https://doi.org/10.1186/s13036-025-00518-8

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