Development and in vitro characterization of humanized antibodies for blocking human TRPM4 channel

Development and in vitro characterization of humanized antibodies for blocking human TRPM4 channel

Abstract Transient receptor potential melastatin 4 (TRPM4) channel, a monovalent cation channel, plays a crucial role in various neurological disorders. We previously showed that TRPM4 activity can be blocked by our antibodies: M4P, which targets rat TRPM4 and M4M, against a similar antigenic epitop...

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Bibliographic Details
Main Authors: Shunhui Wei, Charlene Priscilla Poore, Ravi Kumar Verma, See Wee Low, Bo Chen, Hao Fan, Ping Liao
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
TRPM4 channel
Antigenic epitope
Humanized antibody
Channel blocking
Neurological disorder therapy
Online Access:https://doi.org/10.1038/s41598-025-05256-x
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https://doi.org/10.1038/s41598-025-05256-x

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