Integrator complex subunit 12 knockout overcomes a transcriptional block to HIV latency reversal

Integrator complex subunit 12 knockout overcomes a transcriptional block to HIV latency reversal

The latent HIV reservoir is a major barrier to HIV cure. Combining latency reversal agents (LRAs) with differing mechanisms of action such as AZD5582, a non-canonical NF-kB activator, and I-BET151, a bromodomain inhibitor is appealing toward inducing HIV-1 reactivation. However, even this LRA combin...

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Bibliographic Details
Main Authors: Carley N Gray, Manickam Ashokkumar, Derek H Janssens, Jennifer L Kirchherr, Brigitte Allard, Emily Hsieh, Terry L Hafer, Nancie M Archin, Edward P Browne, Michael Emerman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
HIV
latency
Integrator
Integrator complex
INTS12
transcription elongation
Online Access:https://elifesciences.org/articles/103064
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https://elifesciences.org/articles/103064

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