hNIS-based imaging to monitor treatment with the novel oncolytic virus CF33-hNIS-antiPDL1 in humans with advanced triple negative breast cancer

hNIS-based imaging to monitor treatment with the novel oncolytic virus CF33-hNIS-antiPDL1 in humans with advanced triple negative breast cancer

BackgroundTriple-negative breast cancer (TNBC) is clinically aggressive. CF33-hNIS-antiPDL1, an oncolytic orthopoxvirus, shows robust anti-cancer activity in TNBC xenografts in mice. CF33-hNIS-antiPDL1-infected tumor cells express functional human sodium iodide symporter (hNIS) and are visible by si...

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Bibliographic Details
Main Authors: Jamie Rand, Dave Yamauchi, Shyambabu Chaurasiya, Jianying Zhang, Supriya Deshpande, Leslie Chong, Amanda Seiz, Hans Meisen, Yuman Fong, Yuan Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
triple-negative breast cancer
oncolytic virus
PET
SPECT imaging
Tc-99m
noninvasive imaging
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1565244/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1565244/full

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