Interleukin-1β mediates a tumor-supporting environment prompted by IGF1 in triple-negative breast cancer (TNBC)

Interleukin-1β mediates a tumor-supporting environment prompted by IGF1 in triple-negative breast cancer (TNBC)

Abstract Background The intricate mechanisms that associate obesity with triple-negative breast cancer (TNBC) remain to be disclosed. Considering that obesity is linked with an increased bioavailability of the insulin-like growth factor 1 (IGF1), we evaluated whether IGF1 triggers aggressive feature...

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Main Authors: Domenica Scordamaglia, Marianna Talia, Francesca Cirillo, Azzurra Zicarelli, Adelina Assunta Mondino, Salvatore De Rosis, Marika Di Dio, Francesca Silvestri, Chiara Meliti, Anna Maria Miglietta, Carlo Capalbo, Ernestina Marianna De Francesco, Antonino Belfiore, Marcello Maggiolini, Rosamaria Lappano
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
Interleukin 1β (IL1β)
Triple-negative breast cancer (TNBC)
Cancer associated fibroblasts (CAFs)
Insulin-like growth factor 1 (IGF1)
Discoidin domain receptor 1 (DDR1)
G protein estrogen receptor (GPER)
Online Access:https://doi.org/10.1186/s12967-025-06730-w
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https://doi.org/10.1186/s12967-025-06730-w

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