Five Amino Acid Substitutions in the S1 Unit of Infectious Bronchitis Virus Are Critical Determinants Enhancing Its Adaptation to Vero Cells
The S1 subunit of the spike protein of avian infectious bronchitis virus (IBV) plays a crucial role in determining its host range and cell and tissue tropism. Following the continuous passage of IBV-EP3 through Vero cells over up to 65 generations, a total of 19 amino acid mutations accumulated in t...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
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| Series: | Veterinary Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-7381/12/5/394 |
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