CCL20 expression is elevated in inflammatory bowel disease and attenuated by vitamin D metabolites

CCL20 expression is elevated in inflammatory bowel disease and attenuated by vitamin D metabolites

Abstract Intestinal epithelial overexpression of the Th17 cell chemoattractant CCL20 is implicated in inflammatory bowel disease and influenced by NOD2 mutations in Crohn’s disease. Vitamin D metabolites have been shown to ameliorate inflammatory bowel disease. Considering NOD2 mutations in Crohn’s...

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Main Authors: Johannes Stallhofer, Felix Reichl, Michael Lauseker, Lisa Waldenmaier, Helga Paula Török, Julia Mayerle, Torsten Olszak, Fabian Schnitzler, Iris Frasheri, Simone Breiteneicher, Stephan Brand, Andreas Stallmach, Julia Diegelmann, Florian Beigel
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
C–C motif chemokine ligand 20
CCL20
Vitamin D
Inflammatory bowel disease
Crohn’s disease
Ulcerative colitis
Online Access:https://doi.org/10.1038/s41598-025-05094-x
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https://doi.org/10.1038/s41598-025-05094-x

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