HMGB1 coordinates SASP‐related chromatin folding and RNA homeostasis on the path to senescence

HMGB1 coordinates SASP‐related chromatin folding and RNA homeostasis on the path to senescence

Abstract Spatial organization and gene expression of mammalian chromosomes are maintained and regulated in conjunction with cell cycle progression. This is perturbed once cells enter senescence and the highly abundant HMGB1 protein is depleted from nuclei to act as an extracellular proinflammatory s...

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Main Authors: Konstantinos Sofiadis, Natasa Josipovic, Milos Nikolic, Yulia Kargapolova, Nadine Übelmesser, Vassiliki Varamogianni‐Mamatsi, Anne Zirkel, Ioanna Papadionysiou, Gary Loughran, James Keane, Audrey Michel, Eduardo G Gusmao, Christian Becker, Janine Altmüller, Theodore Georgomanolis, Athanasia Mizi, Argyris Papantonis
Format: Article
Language:English
Published: Springer Nature 2021-06-01
Series:Molecular Systems Biology
Subjects:
3D chromatin folding
loop
replicative senescence
RNA splicing
senescence‐associated secretory phenotype
Online Access:https://doi.org/10.15252/msb.20209760
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https://doi.org/10.15252/msb.20209760

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