Single-cell transcriptomics reveals BMP4-BMPR2 signaling promotes radiation resistance in hematopoietic stem cells following injury

Single-cell transcriptomics reveals BMP4-BMPR2 signaling promotes radiation resistance in hematopoietic stem cells following injury

Abstract High doses of ionizing radiation (IR) cause severe damage to the hematopoietic system. However, the heterogeneity of hematopoietic stem and progenitor cells (HSPCs) in response to IR stress remains largely uncharacterized. Here, we present a dynamic single cell transcriptomic landscape and...

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Main Authors: Yanhua Li, Yunxing Li, Bowen Zhang, Jiahui Zhao, Jinhua Qin, Siao Jiang, Yunqiao Li, Yanzhou Chen, Jisheng Li, Keyi Chen, Yang Lv, Tao Fan, Zuyin Yu, Hao Lu, Cheng Quan, Yiming Lu, Xuetao Pei, Gangqiao Zhou
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60557-z
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https://doi.org/10.1038/s41467-025-60557-z

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