Predicting clozapine-induced adverse drug reaction biomarkers using machine learning

Abstract Clozapine is an atypical antipsychotic used for patients with treatment-resistant schizophrenia. This drug has serious adverse drug reactions (ADRs), including the risk of severe neutropenia (agranulocytosis). Patients who could benefit from clozapine may not be administered it due to conce...

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Bibliographic Details
Main Authors: John-Paul Cooper, Pierre Chue, Arno G. Siraki, Lusine Tonoyan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-09472-3
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