CuBr2-catalysed intramolecular oxidative CN bond formation for synthesis of indoline-2,3-diones and anticancer drug semaxanib under continuous-flow conditions
A new and efficient CuBr2-catalysed continuous-flow method for the synthesis of indoline-2,3-diones is presented. This is an intramolecular oxidative CN bond formation reaction which proceeds via a bromo intermediate, followed by benzylic CH oxidation in presence of molecular oxygen as an oxidant. T...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
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| Series: | Applied Catalysis O: Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950648425000379 |
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