CuBr2-catalysed intramolecular oxidative CN bond formation for synthesis of indoline-2,3-diones and anticancer drug semaxanib under continuous-flow conditions

CuBr2-catalysed intramolecular oxidative CN bond formation for synthesis of indoline-2,3-diones and anticancer drug semaxanib under continuous-flow conditions

A new and efficient CuBr2-catalysed continuous-flow method for the synthesis of indoline-2,3-diones is presented. This is an intramolecular oxidative CN bond formation reaction which proceeds via a bromo intermediate, followed by benzylic CH oxidation in presence of molecular oxygen as an oxidant. T...

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Bibliographic Details
Main Authors: Charu Arya, Moumita Khanra, K. Naveen Kumar, Sharada Prasanna Swain
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Applied Catalysis O: Open
Subjects:
Copper
Semaxanib
Indoline
Anticancer
Flow chemistry
Green chemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S2950648425000379
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