Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5.

Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5.

Reversible post-translational protein modifications such as SUMOylation add complexity to cardiac transcriptional regulation. The homeodomain transcription factor Nkx2-5/Csx is essential for heart specification and morphogenesis. It has been previously suggested that SUMOylation of lysine 51 (K51) o...

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Bibliographic Details
Main Authors: Mauro W Costa, Stella Lee, Milena B Furtado, Li Xin, Duncan B Sparrow, Camila G Martinez, Sally L Dunwoodie, Eleonora Kurtenbach, Tim Mohun, Nadia Rosenthal, Richard P Harvey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024812&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024812&type=printable

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