Evaluating the potential hepatotoxicity from hip implant wear products—An in-vitro and in-vivo study

Evaluating the potential hepatotoxicity from hip implant wear products—An in-vitro and in-vivo study

Total hip replacement (THR) is recognized as an effective treatment for patients suffering from severe arthritis or hip issues, with approximately 2.5 million hip and knee replacements recorded annually (AJJR, 2021). A significant clinical concern associated with THR is the toxicity caused by metal...

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Bibliographic Details
Main Authors: Shriya Thakur, Hemalatha Kanniyappan, Puranjay Gupta, Govindaraj Perumal, Robert Hillwig, Vedant V. Bodke, Salman R. Khetani, Mathew T. Mathew
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Biomaterials and Biosystems
Subjects:
Hip implants
THR
Systemic toxicity
Liver cells
In-vitro models
In-vivo models
Online Access:http://www.sciencedirect.com/science/article/pii/S266653442500008X
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