Physiological Oxygen Levels in the Microenvironment Program Ex Vivo-Generated Conventional Dendritic Cells Toward a Tolerogenic Phenotype

Physiological Oxygen Levels in the Microenvironment Program Ex Vivo-Generated Conventional Dendritic Cells Toward a Tolerogenic Phenotype

Dendritic cells (DCs) are critical regulators of immune homeostasis, balancing tolerance and immunity through antigen presentation and T cell modulation. While the influence of hypoxia (<2% O<sub>2</sub>) on DC function in pathological settings is well-documented, the impact of physio...

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Bibliographic Details
Main Authors: Antonia Peter, Morgane Vermeulen, Mats Van Delen, Amber Dams, Stefanie Peeters, Hans De Reu, Waleed F. A. Marei, Zwi N. Berneman, Nathalie Cools
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
dendritic cells
microenvironment
oxygen
immunometabolism
dendritic-cell based immunotherapy
Online Access:https://www.mdpi.com/2073-4409/14/10/736
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