Different immunogens and prime-boost vaccination strategies affect the efficacy of recombinant candidate vaccines against pathogenic orthopoxviruses

Highlights Recombinant avipoxviruses as putative recombinant vaccines against MPXV. Different prime–boost regimens to improve immunization against orthopoxviruses. Mucosal and intramuscular immunization to enhance the humoral and neutralizing immune response.

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Main Authors: Antonia Radaelli, Carlo Zanotto, Chiara Brambilla, Tommaso Adami, Francesca Paolini, Aldo Venuti, Adriana Manuka, Irsida Mehmeti, Carlo De Giuli Morghen
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Virology Journal
Subjects:
Online Access:https://doi.org/10.1186/s12985-024-02534-4
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author Antonia Radaelli
Carlo Zanotto
Chiara Brambilla
Tommaso Adami
Francesca Paolini
Aldo Venuti
Adriana Manuka
Irsida Mehmeti
Carlo De Giuli Morghen
author_facet Antonia Radaelli
Carlo Zanotto
Chiara Brambilla
Tommaso Adami
Francesca Paolini
Aldo Venuti
Adriana Manuka
Irsida Mehmeti
Carlo De Giuli Morghen
author_sort Antonia Radaelli
collection DOAJ
description Highlights Recombinant avipoxviruses as putative recombinant vaccines against MPXV. Different prime–boost regimens to improve immunization against orthopoxviruses. Mucosal and intramuscular immunization to enhance the humoral and neutralizing immune response.
format Article
id doaj-art-1c1531897baa4c83a54eca993ea56772
institution DOAJ
issn 1743-422X
language English
publishDate 2024-11-01
publisher BMC
record_format Article
series Virology Journal
spelling doaj-art-1c1531897baa4c83a54eca993ea567722025-08-20T02:49:56ZengBMCVirology Journal1743-422X2024-11-0121111210.1186/s12985-024-02534-4Different immunogens and prime-boost vaccination strategies affect the efficacy of recombinant candidate vaccines against pathogenic orthopoxvirusesAntonia Radaelli0Carlo Zanotto1Chiara Brambilla2Tommaso Adami3Francesca Paolini4Aldo Venuti5Adriana Manuka6Irsida Mehmeti7Carlo De Giuli Morghen8Department of Medical Biotechnologies and Translational Medicine, University of MilanDepartment of Medical Biotechnologies and Translational Medicine, University of MilanDepartment of Medical Biotechnologies and Translational Medicine, University of MilanDepartment of Medical Biotechnologies and Translational Medicine, University of MilanUOSD Tumor Immunology and Immunotherapy, HPV UNIT, IRCCS Regina Elena National Cancer InstituteUOSD Tumor Immunology and Immunotherapy, HPV UNIT, IRCCS Regina Elena National Cancer InstituteFaculty of Pharmacy, Catholic University “Our Lady of Good Counsel”Faculty of Pharmacy, Catholic University “Our Lady of Good Counsel”Faculty of Pharmacy, Catholic University “Our Lady of Good Counsel”Highlights Recombinant avipoxviruses as putative recombinant vaccines against MPXV. Different prime–boost regimens to improve immunization against orthopoxviruses. Mucosal and intramuscular immunization to enhance the humoral and neutralizing immune response.https://doi.org/10.1186/s12985-024-02534-4Prime-boost immunization regimensRecombinant vaccines against MPXVOrthopoxvirus vaccinesEnhancement of the immune response
spellingShingle Antonia Radaelli
Carlo Zanotto
Chiara Brambilla
Tommaso Adami
Francesca Paolini
Aldo Venuti
Adriana Manuka
Irsida Mehmeti
Carlo De Giuli Morghen
Different immunogens and prime-boost vaccination strategies affect the efficacy of recombinant candidate vaccines against pathogenic orthopoxviruses
Virology Journal
Prime-boost immunization regimens
Recombinant vaccines against MPXV
Orthopoxvirus vaccines
Enhancement of the immune response
title Different immunogens and prime-boost vaccination strategies affect the efficacy of recombinant candidate vaccines against pathogenic orthopoxviruses
title_full Different immunogens and prime-boost vaccination strategies affect the efficacy of recombinant candidate vaccines against pathogenic orthopoxviruses
title_fullStr Different immunogens and prime-boost vaccination strategies affect the efficacy of recombinant candidate vaccines against pathogenic orthopoxviruses
title_full_unstemmed Different immunogens and prime-boost vaccination strategies affect the efficacy of recombinant candidate vaccines against pathogenic orthopoxviruses
title_short Different immunogens and prime-boost vaccination strategies affect the efficacy of recombinant candidate vaccines against pathogenic orthopoxviruses
title_sort different immunogens and prime boost vaccination strategies affect the efficacy of recombinant candidate vaccines against pathogenic orthopoxviruses
topic Prime-boost immunization regimens
Recombinant vaccines against MPXV
Orthopoxvirus vaccines
Enhancement of the immune response
url https://doi.org/10.1186/s12985-024-02534-4
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