Different immunogens and prime-boost vaccination strategies affect the efficacy of recombinant candidate vaccines against pathogenic orthopoxviruses

Different immunogens and prime-boost vaccination strategies affect the efficacy of recombinant candidate vaccines against pathogenic orthopoxviruses

Highlights Recombinant avipoxviruses as putative recombinant vaccines against MPXV. Different prime–boost regimens to improve immunization against orthopoxviruses. Mucosal and intramuscular immunization to enhance the humoral and neutralizing immune response.

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Bibliographic Details
Main Authors: Antonia Radaelli, Carlo Zanotto, Chiara Brambilla, Tommaso Adami, Francesca Paolini, Aldo Venuti, Adriana Manuka, Irsida Mehmeti, Carlo De Giuli Morghen
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Virology Journal
Subjects:
Prime-boost immunization regimens
Recombinant vaccines against MPXV
Orthopoxvirus vaccines
Enhancement of the immune response
Online Access:https://doi.org/10.1186/s12985-024-02534-4
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https://doi.org/10.1186/s12985-024-02534-4

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