The inhibition of PINK1/Drp1-mediated mitophagy by hyperglycemia leads to impaired osteoblastogenesis in diabetes

The inhibition of PINK1/Drp1-mediated mitophagy by hyperglycemia leads to impaired osteoblastogenesis in diabetes

Summary: Impaired bone quality and increased fracture risk are cardinal features of the skeleton in diabetes mellitus. Hyperglycemia-induced oxidative stress is proposed as a potential underlying mechanism, but the precise pathogenic mechanism remains incompletely understood. In this investigation,...

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Main Authors: Xiao-jing Chen, Yu-ying Yang, Zheng-can Pan, Jing-zun Xu, Tao Jiang, Lin-lin Zhang, Ke-cheng Zhu, Deng Zhang, Jia-xi Song, Chun-xiang Sheng, Li-hao Sun, Bei Tao, Jian-min Liu, Hong-yan Zhao
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:iScience
Subjects:
Physiology
Molecular biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224027469
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http://www.sciencedirect.com/science/article/pii/S2589004224027469

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