Application of Metabolomics in Thyroid Cancer Research
Thyroid cancer is the most common endocrine malignancy with four major types distinguished on the basis of histopathological features: papillary, follicular, medullary, and anaplastic. Classification of thyroid cancer is the primary step in the assessment of prognosis and selection of the treatment....
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/258763 |
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| _version_ | 1832545628157116416 |
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| author | Anna Wojakowska Mykola Chekan Piotr Widlak Monika Pietrowska |
| author_facet | Anna Wojakowska Mykola Chekan Piotr Widlak Monika Pietrowska |
| author_sort | Anna Wojakowska |
| collection | DOAJ |
| description | Thyroid cancer is the most common endocrine malignancy with four major types distinguished on the basis of histopathological features: papillary, follicular, medullary, and anaplastic. Classification of thyroid cancer is the primary step in the assessment of prognosis and selection of the treatment. However, in some cases, cytological and histological patterns are inconclusive; hence, classification based on histopathology could be supported by molecular biomarkers, including markers identified with the use of high-throughput “omics” techniques. Beside genomics, transcriptomics, and proteomics, metabolomic approach emerges as the most downstream attitude reflecting phenotypic changes and alterations in pathophysiological states of biological systems. Metabolomics using mass spectrometry and magnetic resonance spectroscopy techniques allows qualitative and quantitative profiling of small molecules present in biological systems. This approach can be applied to reveal metabolic differences between different types of thyroid cancer and to identify new potential candidates for molecular biomarkers. In this review, we consider current results concerning application of metabolomics in the field of thyroid cancer research. Recent studies show that metabolomics can provide significant information about the discrimination between different types of thyroid lesions. In the near future, one could expect a further progress in thyroid cancer metabolomics leading to development of molecular markers and improvement of the tumor types classification and diagnosis. |
| format | Article |
| id | doaj-art-1c11eb104055488784e498ae341d9428 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-1c11eb104055488784e498ae341d94282025-02-03T07:25:14ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/258763258763Application of Metabolomics in Thyroid Cancer ResearchAnna Wojakowska0Mykola Chekan1Piotr Widlak2Monika Pietrowska3Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, 44-101 Gliwice, PolandMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, 44-101 Gliwice, PolandMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, 44-101 Gliwice, PolandMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, 44-101 Gliwice, PolandThyroid cancer is the most common endocrine malignancy with four major types distinguished on the basis of histopathological features: papillary, follicular, medullary, and anaplastic. Classification of thyroid cancer is the primary step in the assessment of prognosis and selection of the treatment. However, in some cases, cytological and histological patterns are inconclusive; hence, classification based on histopathology could be supported by molecular biomarkers, including markers identified with the use of high-throughput “omics” techniques. Beside genomics, transcriptomics, and proteomics, metabolomic approach emerges as the most downstream attitude reflecting phenotypic changes and alterations in pathophysiological states of biological systems. Metabolomics using mass spectrometry and magnetic resonance spectroscopy techniques allows qualitative and quantitative profiling of small molecules present in biological systems. This approach can be applied to reveal metabolic differences between different types of thyroid cancer and to identify new potential candidates for molecular biomarkers. In this review, we consider current results concerning application of metabolomics in the field of thyroid cancer research. Recent studies show that metabolomics can provide significant information about the discrimination between different types of thyroid lesions. In the near future, one could expect a further progress in thyroid cancer metabolomics leading to development of molecular markers and improvement of the tumor types classification and diagnosis.http://dx.doi.org/10.1155/2015/258763 |
| spellingShingle | Anna Wojakowska Mykola Chekan Piotr Widlak Monika Pietrowska Application of Metabolomics in Thyroid Cancer Research International Journal of Endocrinology |
| title | Application of Metabolomics in Thyroid Cancer Research |
| title_full | Application of Metabolomics in Thyroid Cancer Research |
| title_fullStr | Application of Metabolomics in Thyroid Cancer Research |
| title_full_unstemmed | Application of Metabolomics in Thyroid Cancer Research |
| title_short | Application of Metabolomics in Thyroid Cancer Research |
| title_sort | application of metabolomics in thyroid cancer research |
| url | http://dx.doi.org/10.1155/2015/258763 |
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