5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection.

5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection.

5-Lipoxygenase-derived products have been implicated in both the inhibition and promotion of chronic infection. Here, we sought to investigate the roles of endogenous 5-lipoxygenase products and exogenous leukotrienes during Histoplasma capsulatum infection in vivo and in vitro. 5-LO deficiency led...

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Bibliographic Details
Main Authors: Adriana Secatto, Lilian Cataldi Rodrigues, Carlos Henrique Serezani, Simone Gusmão Ramos, Marcelo Dias-Baruffi, Lúcia Helena Faccioli, Alexandra I Medeiros
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0031701&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0031701&type=printable

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