Discordance in genotypic and phenotypic drug susceptibility results: time to reconsider critical concentration of rifampicin

Discordance in genotypic and phenotypic drug susceptibility results: time to reconsider critical concentration of rifampicin

ABSTRACT The objective of this study is to correlate rpoB mutations found on the new-generation sequencing (NGS) in Mycobacterium tuberculosis (MTB) isolates with minimum inhibitory concentrations (MICs) to the rifampicin (RIF). We assessed the minimum inhibitory concentrations for 151 archived clin...

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Main Authors: Arti Shrivas, Sarman Singh, Jitendra Singh, Prem Shankar, Payal Soni, Syed Beenish Rufai, Anand Maurya, Shashank Purwar
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Series:Microbiology Spectrum
Subjects:
tuberculosis
rifampicin
critical concentration
mutations
minimum inhibitory concentration
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02236-24
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https://journals.asm.org/doi/10.1128/spectrum.02236-24

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