Changes of brain structure and structural covariance networks in Parkinson’s disease with different sides of onset

Changes of brain structure and structural covariance networks in Parkinson’s disease with different sides of onset

BackgroundParkinson’s disease (PD) typically presents with unilateral symptoms in early stages, starting on one side and progressing, with the onset side showing more severe motor symptoms even after bilateralization. This asymmetry may reflect complex interactions among multiple brain regions and t...

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Main Authors: Tianqi Xu, Zhihuai Deng, Yinhui Yu, Wenchao Duan, Zeyu Ma, Haoran Liu, Lianling Li, Moxuan Zhang, Siyu Zhou, Pengda Yang, Xueyan Qin, Zhenyu Zhang, Fangang Meng, Yuchen Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
asymmetry
side-of-onset
surface-based morphometry
structural covariance networks
cortical thickness
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1564754/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2025.1564754/full

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