Impact on the Leishmania mexicana transcriptome due to knockout of genes encoding orthologs of methyltransferases involved in m1A and m5C mRNA modifications

Impact on the Leishmania mexicana transcriptome due to knockout of genes encoding orthologs of methyltransferases involved in m1A and m5C mRNA modifications

Abstract Background Chemical modifications of mRNAs constitute an alternative mechanism for gene expression regulation, which involves proteins responsible for adding, recognizing and removing these modifications. While orthologs of enzymes involved in adding m1A (TRMT6/TRMT61A) and m5C (NSUN2) modi...

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Main Authors: Angela Moreira Bezerra, Ariely Barbosa Leite, Christian Robson de Souza Reis, João Luiz de Lemos Padilha Pitta, Suellen Rodrigues Maran, Nilmar Silvio Moretti, Danielle Maria Nascimento Moura, Antonio Mauro Rezende
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Parasites & Vectors
Subjects:
Chemical modification
m1A
m5C
Gene regulation
mRNA
Leishmania mexicana
Online Access:https://doi.org/10.1186/s13071-025-06969-8
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https://doi.org/10.1186/s13071-025-06969-8

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