Nucleosome spacing can fine-tune higher-order chromatin assembly

Nucleosome spacing can fine-tune higher-order chromatin assembly

Abstract Cellular chromatin displays heterogeneous structure and dynamics, properties that control diverse nuclear processes. Models invoke phase separation of conformational ensembles of chromatin fibers as a mechanism regulating chromatin organization in vivo. Here we combine biochemistry and mole...

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Main Authors: Lifeng Chen, M. Julia Maristany, Stephen E. Farr, Jinyue Luo, Bryan A. Gibson, Lynda K. Doolittle, Jorge R. Espinosa, Jan Huertas, Sy Redding, Rosana Collepardo-Guevara, Michael K. Rosen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61482-x
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https://doi.org/10.1038/s41467-025-61482-x

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