Research Progress in Types, Functions and Detection Techniques of Glycoproteins in Breast Milk

More than 70% of proteins in breast milk are glycosylated, and glycosylation enzymes cleave specific structures that connect proteins to polysaccharides. However, the human digestive system does not secrete glycosylation enzymes. Therefore, glycosylated proteins are more likely to retain their activ...

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Bibliographic Details
Main Author: LIU Xiaojia, ZHANG Xiaomei, ZHANG Minghui, LI Xing, GAO Ziyue, ZHAO Junying, QIAO Weicang, CHEN Lijun
Format: Article
Language:English
Published: China Food Publishing Company 2025-03-01
Series:Shipin Kexue
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Online Access:https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-6-039.pdf
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Summary:More than 70% of proteins in breast milk are glycosylated, and glycosylation enzymes cleave specific structures that connect proteins to polysaccharides. However, the human digestive system does not secrete glycosylation enzymes. Therefore, glycosylated proteins are more likely to retain their activity and exert their functions in the digestive system compared with non-glycosylated proteins. This article introduces the types, composition and content of glycoproteins in breast milk, analyzes the mechanism underlying their biological functions, and reviews recent progress in glycoproteomics. We expect that this review will provide a reference for research on the biological functions of glycoproteins in breast milk.
ISSN:1002-6630