Simultaneous Determination of Candesartan and Hydrochlorothiazide in Human Plasma by HPLC-MS/MS

Simultaneous Determination of Candesartan and Hydrochlorothiazide in Human Plasma by HPLC-MS/MS

Introduction. Combined drugs have the greatest efficacy and safety in arterial hypertension treatment. The combination of candesartan and hydrochlorothiazide (AT1-receptor antagonist and a thiazide diuretic, respectively) provides high efficiency of antihypertensive combination therapy, therefore it...

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Main Authors: P. K. Karnakova, T. N. Komarov, O. A. Archakova, D. S. Shchelgacheva, A. A. Aleshina, N. S. Bagaeva, P. A. Karpova, I. E. Shohin
Format: Article
Language:Russian
Published: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2021-11-01
Series:Разработка и регистрация лекарственных средств
Subjects:
candesartan, hydrochlorothiazide, plasma, blood, hplc-ms/ms, validation, pharmacokinetics
Online Access:https://www.pharmjournal.ru/jour/article/view/1078
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