Anatomic subtype-specific causal effects of endometriosis on ovarian cancer: a two-sample Mendelian randomization study

Anatomic subtype-specific causal effects of endometriosis on ovarian cancer: a two-sample Mendelian randomization study

Abstract While epidemiological studies have associated endometriosis with ovarian cancer risk, the causal relationships across anatomic subtypes and histotypes remain undefined. Using two-sample Mendelian randomization with 84 genetic instruments (F-statistic = 30.01–228.09), we analyzed genome-wide...

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Bibliographic Details
Main Authors: Xu Zhang, Li Wang, Xingxing Ruan, Jie Ding, Jing Wan, Chengfang Xu, Xiaomao Li
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Discover Oncology
Subjects:
Endometriosis subtypes
Ovarian cancer histotypes
Mendelian randomization
Causal inference
Genetic epidemiology
Online Access:https://doi.org/10.1007/s12672-025-03387-1
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https://doi.org/10.1007/s12672-025-03387-1

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