Exploring the Role of Thy‐1 and Its Soluble Form Regarding Fibrosis Severity in Primary Biliary Cholangitis and Metabolic Dysfunction‐Associated Fatty Liver Disease

Exploring the Role of Thy‐1 and Its Soluble Form Regarding Fibrosis Severity in Primary Biliary Cholangitis and Metabolic Dysfunction‐Associated Fatty Liver Disease

ABSTRACT Background and Aim Portal myofibroblasts (PMF) are known to be critical in bile duct injury, but their role in liver fibrogenesis remains underexplored. Thy‐1, an adhesion molecule detected as soluble Thy‐1 (sThy‐1) in serum, is primarily expressed by portal myofibroblasts (PMF) and, to a l...

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Main Authors: Mirjam Kolev, Rahel Bütikofer, Anja Saalbach, Florian Kollert, Matteo Montani, Nasser Semmo
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:JGH Open
Subjects:
liver fibrosis
metabolic dysfunction‐associated liver disease
primary biliary cholangitis
soluble Thy‐1
Thy‐1
Online Access:https://doi.org/10.1002/jgh3.70155
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https://doi.org/10.1002/jgh3.70155

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