Adaptative Divergence of <i>Cryptococcus neoformans</i>: Phenetic and Metabolomic Profiles Reveal Distinct Pathways of Virulence and Resistance in Clinical vs. Environmental Isolates

Adaptative Divergence of <i>Cryptococcus neoformans</i>: Phenetic and Metabolomic Profiles Reveal Distinct Pathways of Virulence and Resistance in Clinical vs. Environmental Isolates

<i>Cryptococcus neoformans</i> is a life-threatening fungal pathogen that primarily affects immunocompromised individuals. While antiretroviral therapy has reduced incidence in developed nations, fluconazole-resistant strains and virulent environmental isolates continue to pose challenge...

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Main Authors: Camila Botelho Miguel, Geovana Pina Vilela, Lara Mamede Almeida, Mariane Andrade Moreira, Glicélia Pereira Silva, Jamil Miguel-Neto, Melissa Carvalho Martins-de-Abreu, Ferdinando Agostinho, Javier Emilio Lazo-Chica, Mariana Santos Cardoso, Siomar de Castro Soares, Aristóteles Góes-Neto, Wellington Francisco Rodrigues
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Journal of Fungi
Subjects:
<i>Cryptococcus neoformans</i>
phenetic analysis
metabolomics
clinical isolates
environmental isolates
antifungal resistance
Online Access:https://www.mdpi.com/2309-608X/11/3/215
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