Time- and dose-dependent activation of the NLRP3 and MyD88/NF-κB pathways by Trueperella pyogenes membrane vesicles in bovine endometrial epithelial cells

Time- and dose-dependent activation of the NLRP3 and MyD88/NF-κB pathways by Trueperella pyogenes membrane vesicles in bovine endometrial epithelial cells

Abstract Trueperella pyogenes is an opportunistic pathogen frequently associated with bovine endometritis, yet the mechanisms by which it induces uterine inflammation remain incompletely understood. In this study, we investigated the effects of T. pyogenes and its membrane vesicles (MVs) on bovine e...

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Bibliographic Details
Main Authors: Dengfu Li, Haixia Li, Zhu Wang, Yuchen Huang, Chenchong Zhao, Hongxia Zhang, Yanan Zhao, Naihui Zhu, Xirong Tang, Yaping Jin, Dong Zhou
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Veterinary Research
Subjects:
Trueperella pyogenes
membrane vesicles
NLRP3 inflammasome
MyD88/NF-κB
endometritis
Online Access:https://doi.org/10.1186/s13567-025-01587-9
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https://doi.org/10.1186/s13567-025-01587-9

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