Regulation of microtubule nucleation in glioblastoma cells by ARF GTPase-activating proteins GIT1 and GIT2 and protein kinase C

Regulation of microtubule nucleation in glioblastoma cells by ARF GTPase-activating proteins GIT1 and GIT2 and protein kinase C

Abstract Background G protein-coupled receptor kinase-interacting proteins (GITs) function as GTPase-activating proteins (GAPs) for small GTPases of the ADP-ribosylation factor (Arf) family. While GIT proteins (GIT1 and GIT2) regulate both cell migration and microtubule organization, their correspon...

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Main Authors: Vadym Sulimenko, Eduarda Dráberová, Vladimíra Sládková, Tetyana Sulimenko, Věra Vosecká, Omar Skalli, Pavel Dráber
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cancer Cell International
Subjects:
Glioblastoma cells
Centrosomes
G protein-coupled receptor kinase-interacting proteins (GITs)
Microtubule nucleation
Protein kinase C (PKC)
Online Access:https://doi.org/10.1186/s12935-025-03740-y
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https://doi.org/10.1186/s12935-025-03740-y

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