Isolated tumor cell clusters (ITC) in lymph nodes and PD-L1 expression on tumor-associated immune cells are prognostic factors for microsatellite instable-high gastric cancers

Isolated tumor cell clusters (ITC) in lymph nodes and PD-L1 expression on tumor-associated immune cells are prognostic factors for microsatellite instable-high gastric cancers

Background: Microsatellite instable-high (MSI-H) gastric cancer (GC) represents a distinct subgroup. However, controversy exists regarding the role of MSI in GCs, and the factors leading to internal prognostic differences among MSI-H GCs are rarely studied. Methods: We identified 53 MSI-H cases from...

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Bibliographic Details
Main Authors: Menghan Cui, Yangli Zhou, Yin Han, Nannan Chen, Min Zhao, Yan Wang, Fengxia He
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Translational Oncology
Subjects:
Microsatellite instability (MSI)
Isolated tumor cell clusters (ITC)
Programmed death-ligand 1 (PD-L1)
Gastric cancer
Prognosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001962
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