Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.

Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.

Activation-induced cytidine deaminase (AID) expressed by germinal center B cells is a central regulator of somatic hypermutation (SHM) and class switch recombination (CSR). Humans with AID mutations develop not only the autosomal recessive form of hyper-IgM syndrome (HIGM2) associated with B cell hy...

Full description

Saved in:
Bibliographic Details
Main Authors: Koji Hase, Daisuke Takahashi, Masashi Ebisawa, Sayaka Kawano, Kikuji Itoh, Hiroshi Ohno
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-08-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0003033
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1371/journal.pone.0003033

Similar Items