Celecoxib disrupts temporal coordination of TGF-β/α-SMA signaling in skeletal muscle repair: a time-dependent study of fibrosis and inflammation

Celecoxib disrupts temporal coordination of TGF-β/α-SMA signaling in skeletal muscle repair: a time-dependent study of fibrosis and inflammation

Abstract Background The role of cyclooxygenase-2 (COX-2) inhibitors in skeletal muscle repair remains controversial due to their potential dual effects on inflammation and fibrosis. This study investigates the time-dependent impacts of the selective COX-2 inhibitor celecoxib on skeletal muscle regen...

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Bibliographic Details
Main Authors: Jia Li, Huan Chen, Qianying Xiong, Jinzhong Ni, Fangyun Sun, Xin Gong, Huachun Miao
Format: Article
Language:English
Published: BMC 2025-08-01
Series:European Journal of Medical Research
Subjects:
Skeletal muscle
Contusion
Celecoxib
Fibrosis
Inflammation
COX-2
Online Access:https://doi.org/10.1186/s40001-025-02996-4
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https://doi.org/10.1186/s40001-025-02996-4

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