CO confers neuroprotection via activating the PERK-calcineurin pathway and inhibiting necroptosis

CO confers neuroprotection via activating the PERK-calcineurin pathway and inhibiting necroptosis

Abstract Neurodegenerative diseases, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD), are marked by progressive neuronal loss. Regulated cell death programs (i.e., necroptosis) as well as homeostatic mechanisms (i.e., autophagy) can modulate disease pathogenesis. Low-dose carbon monoxi...

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Main Authors: Jeongmin Park, LiHua Jin, Hyun-Chul Song, Yingqing Chen, Eun Young Jang, Gyu Hwan Park, Chae Ha Yang, Stefan W. Ryter, Jeong Woo Park, Min Zheng, Yeonsoo Joe, Hun Taeg Chung
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02530-9
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https://doi.org/10.1038/s41420-025-02530-9

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