Decoding the epigenetic-immune nexus in hepatocellular carcinoma: a Mendelian randomization study reveals BTN3A2, S100A12 and TRIM27 as white blood cell regulators

Decoding the epigenetic-immune nexus in hepatocellular carcinoma: a Mendelian randomization study reveals BTN3A2, S100A12 and TRIM27 as white blood cell regulators

Abstract Background Hepatocellular carcinoma accounts for 90% of primary liver malignancies and ranks as the fourth leading cause of global cancer mortality. DNA methylation drives HCC pathogenesis by orchestrating tumor suppressor silencing and oncogenic pathway activation, fundamentally governing...

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Main Authors: Yang Qiu, Haiyan Zhang, Xiao Yu, Jielu Pan, Dinghong Xiao, Hongyu Miao, Ruiqing Wang, Nan Shen, Peimin Pu, Yinling Zhou, Zhidong Liu, Lin He, Lianjun Xing
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
Hepatocellular carcinoma
Tumor microenvironment
DNA methylation
Mendelian randomization
White blood cell
Immunotherapy targets
Online Access:https://doi.org/10.1186/s12885-025-14693-w
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