Decoding the epigenetic-immune nexus in hepatocellular carcinoma: a Mendelian randomization study reveals BTN3A2, S100A12 and TRIM27 as white blood cell regulators

Decoding the epigenetic-immune nexus in hepatocellular carcinoma: a Mendelian randomization study reveals BTN3A2, S100A12 and TRIM27 as white blood cell regulators

Abstract Background Hepatocellular carcinoma accounts for 90% of primary liver malignancies and ranks as the fourth leading cause of global cancer mortality. DNA methylation drives HCC pathogenesis by orchestrating tumor suppressor silencing and oncogenic pathway activation, fundamentally governing...

Full description

Saved in:
Bibliographic Details
Main Authors: Yang Qiu, Haiyan Zhang, Xiao Yu, Jielu Pan, Dinghong Xiao, Hongyu Miao, Ruiqing Wang, Nan Shen, Peimin Pu, Yinling Zhou, Zhidong Liu, Lin He, Lianjun Xing
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
Hepatocellular carcinoma
Tumor microenvironment
DNA methylation
Mendelian randomization
White blood cell
Immunotherapy targets
Online Access:https://doi.org/10.1186/s12885-025-14693-w
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12885-025-14693-w

Similar Items