Characterizing the pharmacological interaction of the antimalarial combination artefenomel-piperaquine in healthy volunteers with induced blood-stage Plasmodium falciparum to predict efficacy in patients with malaria

Characterizing the pharmacological interaction of the antimalarial combination artefenomel-piperaquine in healthy volunteers with induced blood-stage Plasmodium falciparum to predict efficacy in patients with malaria

Abstract Background The combination antimalarial artefenomel-piperaquine failed to achieve target efficacy in a phase 2b study in Africa and Vietnam. We retrospectively evaluated whether characterizing the pharmacological interaction of this antimalarial combination in a volunteer infection study (V...

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Main Authors: Azrin N. Abd-Rahman, Daniel Kaschek, Anne Kümmel, Rebecca Webster, Adam J. Potter, Anand Odedra, Stephen D. Woolley, Stacey Llewellyn, Lachlan Webb, Louise Marquart, Stephan Chalon, Myriam El Gaaloul, James S. McCarthy, Jörg J. Möhrle, Bridget E. Barber
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Medicine
Subjects:
Artefenomel
Piperaquine
Antimalarial
Combination
Volunteer infection study
Pharmacokinetics
Online Access:https://doi.org/10.1186/s12916-024-03787-0
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https://doi.org/10.1186/s12916-024-03787-0

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