(p)ppGpp and DksA play a crucial role in reducing the efficacy of β-lactam antibiotics by modulating bacterial membrane permeability

(p)ppGpp and DksA play a crucial role in reducing the efficacy of β-lactam antibiotics by modulating bacterial membrane permeability

ABSTRACT The key signaling molecules in the bacterial stress-sensing pathway, the alarmone (p)ppGpp and the transcription factor DksA, play a crucial role in bacterial survival during nutritional deprivation and exposure to xenobiotics by modulating cellular metabolic pathways. In Vibrio cholerae, (...

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Main Authors: Meenal Chawla, Jyoti Verma, Shashi Kumari, Tushar Matta, Tarosi Senapati, Prabhakar Babele, Yashwant Kumar, Rupak K. Bhadra, Bhabatosh Das
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:Microbiology Spectrum
Subjects:
Vibrio cholerae
stringent response
(p)ppGpp
DksA
antibiotics
metabolome
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01169-24
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https://journals.asm.org/doi/10.1128/spectrum.01169-24

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