Anti-tumor activity of phenoxybenzamine and its inhibition of histone deacetylases.

Anti-tumor activity of phenoxybenzamine and its inhibition of histone deacetylases.

The principal finding from this study was the recognition that the α-adrenergic antagonist, phenoxybenzamine, possesses histone deacetylase inhibitory activity. Phenoxybenzamine is approved by the United States Food and Drug Administration for the treatment of hypertensive crises associated with tum...

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Bibliographic Details
Main Author: Mario A Inchiosa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198514/1/pone.0198514.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T134502Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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