Glypican-3 is a key tuner of the Hedgehog pathway in COPD

Glypican-3 is a key tuner of the Hedgehog pathway in COPD

Hedgehog (HH) pathway is involved in pulmonary development and lung homeostasis. It orchestrates airway epithelial cell (AEC) differentiation and contributes to respiratory pathogenesis. The core elements Gli2, Smo, and Shh were found altered in the bronchial epithelium of patients with chronic obst...

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Bibliographic Details
Main Authors: Laure M.G. Petit, Lynda Saber Cherif, Maëva A. Devilliers, Sarah Hatoum, Julien Ancel, Gonzague Delepine, Anne Durlach, Xavier Dubernard, Jean-Claude Mérol, Christophe Ruaux, Myriam Polette, Gaëtan Deslée, Jeanne-Marie Perotin, Valérian Dormoy
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Heliyon
Subjects:
COPD
Airway epithelial cells
Hedgehog
GPC3
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024175950
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