Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE

Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE

Abstract Tuberculosis (TB), a leading cause of death among infectious diseases globally, is caused by Mycobacterium tuberculosis (Mtb). The pathogenicity of Mtb is largely attributed to its complex cell envelope, which includes a class of glycolipids called phosphatidyl-myo-inositol mannosides (PIMs...

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Main Authors: Yaqi Liu, Chelsea M. Brown, Nuno Borges, Rodrigo N. Nobre, Satchal Erramilli, Meagan Belcher Dufrisne, Brian Kloss, Sabrina Giacometti, Ana M. Esteves, Cristina G. Timóteo, Piotr Tokarz, Rosemary J. Cater, Todd L. Lowary, Yasu S. Morita, Anthony A. Kossiakoff, Helena Santos, Phillip J. Stansfeld, Rie Nygaard, Filippo Mancia
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57843-1
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https://doi.org/10.1038/s41467-025-57843-1

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